Position Title: Senior Scientist, Immunopeptidome Development
Company: Regeneron Pharmaceuticals, Inc.
Location: Tarrytown, NY

Overview: Regeneron is looking for a highly motivated Senior Scientist who will use our pioneering facilities and technology to perform qualitative and quantitative mass spectrometry experiments focusing on autoimmune, infectious disease and oncology targets. In this role, your primary responsibility will be to apply the latest mass spectrometry techniques for the discovery and validation of novel disease specific antigens from human tissues and cell lines as well as to develop innovative techniques and investigate innovative technologies to enhance our target discovery efforts.

A Typical Day in the Role of Sr Scientist Might Look Like:

• Daily operation of state-of-the-art LC-MS technologies.
• Method development and optimization, including automation of current technologies.
• Preparation of MS samples from a variety of samples, including sample pre-fractionation and proteolytic digestion
• Affinity purification of endogenous proteins/peptides from a variety of samples (i.e., patient tissue biopsies, animal specimens, and cultured cells)
• Immunopeptidome research and technology development
• Independent analysis of multidimensional proteogenomics data applying computational approaches. Knowledge of R and Python is desirable.
• Work closely within and across scientific fields to design and perform analyses.
• Present data packages and conclusions to internal and external collaborators; prepare results for presentation at conferences and publication.

This Role Might Be For You If You Have:

• Strong organizational skills and attention to detail
• Able to work effectively in a fast-paced industry environment.
• Self-motivated, self-disciplined, and able to function independently, as well as part of a team.
• Strategic agility, strong critical thinking and problem solving.
• Ability to prioritize, multi-task, and work in an evolving environment.

This role requires a PhD in biology, biochemistry, biotechnology, or medicine with 0-3 years, a MS with 5-7+years or a BS with 7-10+years of relevant experience. Skill in the operation of an HPLC and mass spectrometer (LC-MS) highly preferred. Knowledge in autoimmunity and immunology desirable. Experience in basic MS sample preparation and analysis a plus. Experience with sample preparation for immunoprecipitation, Mass Spectrometric data analysis using Xcalibur, PEAKS, Skyline and general DB search engine tools preferred. Prior Immunopeptidomics experience is a plus. Expertise in large-scale data analysis of NGS (Whole Exome sequencing, RNA-seq, and MS proteomics) is a plus.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Contact Information: John Breese, Associate Manager, Talent Acquisition Regeneron Pharmaceuticals, Inc
john.breese@regeneron.com / Office: 914-418-0414; Cell: 914-255-1203

Link to Full Description 

Position Title: Postdoctoral Researcher
Company: Systems Chronobiology, Faculty of Medicine, Ludwig-Maximilian-University  
Location: Munich, Germany

Overview: 
We are looking for a motivated postdoctoral researcher with mass spectrometry-based proteomics skills to work on a multidisciplinary project to identify molecular markers of brain activity during sleep.

Job Posting, Qualifications & Application Details can be found here.

Visit the Ludwig-Maximilian-University website for more information.

Position Title: Postdoctoral Position in Proteomics/Cellular Signaling
Company: Huttenhain Lab at in the Department of Molecular and Cellular Physiology at Stanford University School of Medicine
Location: Stanford, CA, USA

Overview:
The Huttenhain Lab in the Department of Molecular & Cellular Physiology is looking for postdoctoral fellows to study mechanisms of intracellular signal integration through G protein-coupled receptors (GPCRs) using cutting edge mass spectrometry-based proteomics, functional genomics, and molecular biology techniques. Applicants with expertise and interest in either (1) mass spectrometry-based proteomics, (2) molecular and cell biology including neuroscience, GPCRs, functional genomics or related techniques, or (3) computational biology are encouraged to apply.

Lab overview: 

The communication between cells and their environment depends on decoding of extracellular cues into intracellular signaling cascades that are integrated through dynamic and context-specific networks driving the cellular responses. Given the complexity and dynamic state of signaling networks, the current understanding of their constituents and how they are spatiotemporally regulated in the cell as a result of a specific input is incomplete.The Huttenhain lab, which will launch in April 2023 in the Molecular & Cellular Physiology Department (https://med.stanford.edu/mcp.html) at Stanford Medicine, studies mechanisms of intracellular signal integration through G protein-coupled receptors (GPCRs), the largest family of membrane receptors mediating most of our physiological responses to hormones, neurotransmitters and environmental stimulants. We employ an interdisciplinary approach to probe, model, and predict how signaling network dynamics translate extracellular cues sensed by GPCRs into specific phenotypic outputs. Developing quantitative proteomics approaches to capture the spatiotemporal organization of signaling networks and combining these with functional genomics and molecular biology techniques to study their impact on physiology, we aim to better understand GPCR signaling and to provide a solid foundation for the design and testing of novel therapeutics targeting GPCRs with higher specificity and efficacy.

Relevant publications:

Lobingier B, Hüttenhain R, Eichel K, Ting AY, Miller KB, von Zastrow M, Krogan NJ. (2017) An approach to spatiotemporally resolve protein interaction networks in living cells. Cell 169, 350-360. PMC5616215.

Polacco BJ, Lobingier BT, Blythe EE, Abreu N, Xu J, Li Q, Naing ZZC, Shoichet BK, Levitz J, Krogan NJ, Von Zastrow M, Hüttenhain R. (2022) Profiling the diversity of agonist-selective effects on the proximal proteome environment of G protein-coupled receptors. bioRxiv 2022.03.28.486115

Specific postdoctoral projects may include:

• Develop quantitative proteomics approaches to map spatiotemporally resolved interaction and signaling networks of GPCRs.
• Mapping signaling network dynamics of GPCRs in neuronal systems to uncover novel regulators and mechanisms of neuromodulation.
• Discover mechanisms how diverse ligands targeting GPCRs elicit diverse phenotypic responses.
• Develop computational approaches to model spatiotemporally resolved signaling networks.

Academic environment:

Stanford University provides a highly stimulating scientific environment that fosters collaborations and the exchange of ideas within and across disciplines. The Molecular & Cellular Physiology Department (https://med.stanford.edu/mcp.html) offers a world-class scientific environment and supports postdoctoral scholars throughout their postdoc with mentoring and training programs, seminar series, and annual retreats. The Huttenhain lab is committed to foster an inclusive, respectful, and collaborative environment with passion for science and mentorship. Trainees will have access to an outstanding infrastructure and resources including dedicated state-of-the-art mass spectrometers.

Required Qualifications:

• Ph.D. in life sciences, biomedical sciences, computer science, or a related discipline.
• Experience and publication record in neuroscience, proteomics, genetics, molecular biology, and/or computational biology.
• Ability to work well in a multidisciplinary, diverse, and collaborative research environment.
• A genuine passion for science, and creative thinking.
• Being self-motivated.
• Strong oral and written communication skills.

Required Application Materials:

• Cover letter that includes a description of relevant research experience and research interests.
• Curriculum vitae (including a complete publication list).
• Names and contact information for 2-3 references.

More information:

https://postdocs.stanford.edu/prospective/opportunities/open-postdoctoral-position-faculty-mentor-ruth-huttenhain

Ruth Huttenhain, Assistant Professor, ruthh@stanford.edu

Twitter: @rhuttenhain

Position Title: Postdoc in Proteomics and Leukemia
Company: Lund University
Location: Lund, Sweden  

Overview:
An exciting opportunity for a postdoctoral fellow is available in the Proteomic Hematology group of Senior Lecturer Jenny Hansson at Lund Stem Cell Center within Lund University. We are seeking a highly motivated postdoc with a strong background in hematopoiesis or mass spectrometry-based proteomics to join the laboratory.

Background:

Infant leukemia arising during the first year of life is a blood cancer associated with very poor prognosis. New therapeutic options that are tailored to the biology of the disease are essential to improve patient outcomes. A promising avenue to exploit therapeutically is the interdependence of the leukemic cells and their local microenvironment (niche).

Your project:

This project aims to advance the understanding of the proteomic interplay between leukemic cells and their niche across fetal and infant life. The fellow will study the developmental leukemia niche and investigate the therapeutic efficacy of a disturbance of the interconnected leukemia-promoting protein networks.

The institute:

Lund is a European hub for research.

Lund University was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. The University has around 46 000 students and more than 8 400 staff. As postdoc in the Proteomics Hematology group, you will be part of a stimulating scientific community within Lund Stem Cell Center, a strategic center of excellence in life science, with a strong international position in blood and stem cell research. Career development courses and workshops will be available to the postdoctoral fellow through the Lund Research School in Stem Cell Biology, and opportunities will be given to apply for own research grants. The postdoc will have access to state-of-the-art equipment, facilities, and infrastructure, including next-generation mass spectrometry instrumentation. We are looking for candidates to contribute to this dynamic and inclusive environment.

The following qualifications are required:

• Proven excellence in either hematopoiesis or mass spectrometry-based proteomics. Experience in both fields is an advantage.
• Excellent verbal and written communication skills in English.
• High willingness to learn new things.
• Good cooperative ability and ability to take initiatives.
• PhD degree within technical biology, analytical chemistry, molecular biology, biomedicine, cell biology, or similar.
• The PhD degree must not be older than 3 years.
• The applicant must not have been employed at Lund University in the past 2 years.

The following are advantageous (not required):

• -PhD in proteomics and/or hematopoiesis.
• Practical experience with preparation of biological samples for mass spectrometric analysis and/or practical experience with isolation and transplantation of hematopoietic stem and progenitor cells.
• Good theoretical knowledge in advanced mass spectrometry and/or practical experience with advanced flow cytometry.
• Experience with modern quantitative proteomic analysis and/or experience with cell culture of hematopoietic cells.
• Experience with analysis of large-scale proteomics data.
• Practical experience with Orbitrap MS and Dionex Ultimate 3000 nLC
• Experience of molecular biology approaches such as proximity labelling assays, immunoprecipitation, Lysosome Targeting Chimera (LYTAC) or other.

Written application, including reference number V2023/528, is to be sent via e-mail to jenny.hansson@med.lu.se and must include:

PhD diploma, CV, personal letter stating the reasons why the project suits the applicant (maximum one page), list of publications, and two references.

Close date: 23.04.2023

More information:

https://www.intramed.lu.se/forska/anslag-och-stipendier/stipendier-fran-fakulteten Reference V 2023/528

Jenny Hansson, Senior Lecturer, jenny.hansson@med.lu.se

Twitter: @HanssonLab

Lund Stem Cell Center: https://www.stemcellcenter.lu.se

Position Title: Senior Scientist / Principal Scientist, Chemical Biology/Chemoproteomics
Company: Dundad Therapeutics, Ltd
Location: Cambridge, UK

Overview: 
We are looking to hire a Chemical Biology/Chemoproteomics Senior / Principal Scientist to play a key part in future success of Dunad by developing and applying cutting-edge chemical biology and chemoproteomics methods with Dunad’s Claymor™ Platform – our proprietary approach to covalency and mono-valent targeted protein degradation – to accelerate our early stage pipeline. You will be responsible for designing experiments to take advantage of Dunad’s existing chemoproteomics platform as well as developing new chemical biology capabilities. You will support and strengthen the company's internal programmes as well as Dunad’s pharma collaborations. You will help us define and refine our internal target pipeline as well as provide essential support for our Drug Discovery programmes. Importantly, you will be a key part of a close-knit, patient-focused team of drug discovery scientists.

Key Responsibilities/Deliverables include:

• Contribute to the design and development of Dunad’s chemoproteomics platform and capabilities.
• Design and develop innovative chemical biology approaches, tailored to the Dunad Claymor platform, to deliver new targets and chemical starting points for drug discovery.
• Work with Dunad’s bioinformatics team to develop and apply world-class proteomics data analysis and machine learning / AI capabilities to accelerate quality target/hit-discovery.
• Work with our CRO partners and academic collaborators to develop new chemoproteomics and chemical biology capabilities for the Dunad Claymor platform – our proprietary approach to mono-valent targeted protein degradation.
• Communicate efficiently with all internal and external stakeholders and be a key member of the Drug Discovery project teams at Dunad.

Qualifications, Skills and Experience:

• PhD + >2 years’ experience in chemistry, chemical biology, chemoproteomics or a closely related subject.
• Deep experience in cutting edge chemical biology approaches for target identification, validation and hit finding.
• Experience with a variety of MS chemoproteomics methods. Experience with covalent drug discovery or protein degradation modalities a plus.
• Experience collaborating with diverse teams of drug discovery experts, with a track record of delivery.
• Ability to independently design experiments and present results as part of wider drug discovery team.
• Problem solver, team player with strong communication skills.

What you'll get in return:

The job title and compensation will be aligned with biotechnology industry practices, offering you a competitive salary, bonus, and equity. You will be a key member of the Drug Discovery team at a cutting-edge company that has rapid expansion plans!

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Position Title: Assistant or Associate Professor Proteomics & Tumor Immunology (0.8 – 1.0 FTE)
Company: Department of Pharmaceutical Sciences, Biomolecular Mass Spectrometry and Proteomics, Utrecht University
Location: Utrecht, Netherlands 

Overview: Within the Department of Pharmaceutical Sciences, we are looking for a new faculty member to join our Biomolecular Mass Spectrometry and Proteomics group. Our research programme is part of the renowned Utrecht Institute for Pharmaceutical Sciences (UIPS).

Your focus in this position will be on proteomics with applications in tumor immunology and cancer. As a mass spectrometry expert, you will pursue opportunities for proteomics research in areas related to antigen presentation, tumor micro-environments, secretomics, single cell and spatial proteomics, and systems and quantitative biology. In addition, you are skilled in analytical and computational method development and desire to further contributions in these areas.

You will strengthen the excellent international scientific profile of UIPS and its central mission of studying molecular mechanisms of disease. You will establish collaborations within UIPS, the Faculty of Science , the UMCU, the Princess Maxima Centre, the Hubrecht Institute, and with other national and international institutes, in particular in connection to the ONCODE-PACT programme.

You will participate in the organization and management activities related to UIPS research and education programs and strengthen the Biomolecular Mass Spectrometry and Proteomics group. You are enthusiastic to lead teaching activities at both BSc and MSc level and supervise research projects of Postdoctoral Researchers, PhD candidates and MSc students.

We are open to applicants at both junior and more matured level of their career stages. In addition to the experience you bring, it is essential that you make a positive contribution to our research group with your passion for research and teaching.

Qualifications:

We would like you to meet the following criteria:

A PhD in Pharmaceutical Sciences or a related field.

You have an internationally acknowledged research line with a strong publication and funding record.

You are an active player in international scientific communities.

Strong communication skills.

Supportive to create a collaborative, sustainable and inclusive work environment.

Link to Full Description:

https://www.uu.nl/en/organisation/working-at-utrecht-university/jobs/assistant-or-associate-professor-proteomics-tumor-immunology-08-10-fte