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  • 01 Dec 2020 2:57 PM | Anonymous member (Administrator)

    Position Title: Postdoctoral Mass Spectrometry Position
    Company: National Center for Advancing Translational Science at the National Institutes of Health
    Location: Rockville Maryland

    The National Center for Advancing Translational Sciences (NCATS), a major research component of the National Institutes of Health, seeks applications from qualified candidates to fill a postdoctoral mass spectrometry position in the Analytical Chemistry Core Facility within NCATS’ Division of Preclinical Innovation in Rockville, Maryland. The selected candidate must have expertise in mass spectrometry, high-performance liquid chromatography (HPLC) and proteomics fields. Applicants with additional expertise in protein biochemistry, automation systems and high-throughput screening will receive preferential consideration.

    The Analytical Chemistry Core Facility maintains a state-of-the-art laboratory, the mission of which is to support chemistry research throughout the Center. The laboratory has a variety of instrumentation utilizing various analytical techniques, including liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, high-resolution mass spectrometry and nuclear magnetic resonance to facilitate early-stage chemical development. Initially focused on small-molecule purification and analysis, the laboratory’s capabilities have expanded to other therapeutic modalities, such as peptides, proteins, antibody-drug conjugates and lipids. The laboratory manages several cutting-edge mass spectrometers with the capability to perform high-throughput sample analysis, peptide and protein analysis (top-down and bottom-up), post-translational modification analysis, multiple reaction monitoring (MRM), proteomics, metabolomics, and ultra-high-resolution analysis of small molecules. NCATS’ goal is to increase the productivity, efficiency and integrity of chemistry efforts by optimizing workflows and integrating automated processes.

    Core Responsibilities
    The postdoctoral fellow will work as part of a multidisciplinary team of innovative scientists using the available resources to develop novel methods and assays for high-throughput proteomics analysis and mass spectrometry-based compound screening. The postdoctoral fellow will be expected to work independently as a well-trained problem solver in the areas of mass spectrometry and HPLC. He or she will manage, troubleshoot and regularly maintain the instrumentation. The fellow will be expected to prepare samples of various modalities prior to analysis. The fellow also will be required to keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she will draft technical reports, manuscripts and patent applications, as well as present work at internal and external meetings.

    The successful applicant must possess a Ph.D. in analytical chemistry, biochemistry or a related discipline, with a focus in mass spectrometry and have relevant research experience. Candidates should possess extensive proteomics experience, including sample preparation, post-translational modification analysis and data analysis, using Proteome Discoverer, MaxQuant, Mascot and/or Skyline. Direct experience with ultra-HPLC/nano-HPLC instrumentation is a must. Familiarity with the RapidFire high-throughput sampling system and protein biochemistry is necessary. Training in the areas of metabolomics, lipids analysis, MRM, intact protein and protein top-down analysis is desirable. The ideal candidate should be self-motivated, possess a strong work ethic, have a keen attention to detail, and be able to work on multiple projects simultaneously. Excellent analytical, organizational and time-management skills are required. The candidate must possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants must be eligible to work in the United States for any employer.

    How to Apply
    Please submit a cover letter describing your interest in the position, including a research summary (1–2 pages); a current curriculum vitae and complete bibliography; and the names and contact information for at least three references to Dr. Christopher LeClair at ncats_info@mail.nih.gov.

    The review of applications will begin immediately and will continue until the position is filled.

    Job posting link: https://ncats.nih.gov/jobs#postdoc-mass-spec

    The NIH is dedicated to building a diverse community in its training and employment programs. NIH is an Equal Opportunity Employer.

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