urine proteome initiative

Overall aim: To facilitate the advancement in urinary protein analysis using different technologies, to explore the associations with different physiological and pathophysiological states, and to help the application of urinary protein biomarkers in clinics.

Current lines of work:

The UPI has been sharing recent publications on urine proteomics in basic research and clinical applications of urinary biomarkers in various discussion groups.

Collection of UPI papers:

• Gao Y. Urine—an untapped goldmine for biomarker discovery? Sci China Life Sci, 2013, 56: 1145–1146.
• Gao Y.（Editor） Urine Promising Biomarker Source for Early Disease Detection 10.1007/978-981-13-9109-5.
• Jia LL et al. Urimem, a membrane that can store urinary proteins simply and economically, makes the large-scale storage of clinical samples possible. Sci China Life Sci, March 2014, 57(3): 336–339.
• Zhao M et al. A comprehensive analysis and annotation of human normal urinary proteome. Sci Rep. 2017 Jun 8;7(1):3024.
• Shimura T et al. Novel urinary protein biomarker panel for early diagnosis of gastric cancer. Br J Cancer. 2020 Nov;123(11):1656-1664. 
• Virreira Winter S et al. Urinary proteome profiling for stratifying patients with familial Parkinson's disease. EMBO Mol Med. 2021 Mar 5;13(3):e13257.
• Bi X et al. Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19. Cell Rep. 2022 Jan 18;38(3):110271.
• Sun Y et al. Noninvasive urinary protein signatures associated with colorectal cancer diagnosis and metastasis. Nat Commun. 2022 May 19;13(1):2757.
• Fan H et al. Urine proteomic signatures predicting the progression from premalignancy to malignant gastric cancer. EBioMedicine. 2022 Dec;86:104340.
• Njoku K, et al. Quantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women. Br J Cancer. 2023 May;128(9):1723-1732.
• Tian W et al. Immune suppression in the early stage of COVID-19 disease. Nat Commun. 2020 Nov 17;11(1):5859.
• Liu Y et al. A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options. Sci China Life Sci. 2022 Sep;65(9):1866-1880.
• Debernardi S et al. A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: a case-control study. PLoS Med. 2020 Dec; 17(12): e1003489.
• Schilling K et al. Urine metallomics signature as an indicator of pancreatic cancer. Metallomics 2020; DOI:10.1039/d0mt00061b. 
• Arasaradnam R et al. Non-invasive Diagnosis of Pancreatic Cancer Through Detection of Volatile Organic Compounds in Urine. Gastroenterology, 2018 Feb;154(3):485-487.