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Publications Publications


Leadership and Team members


Maggie Lam, PhD 

University of Colorado, Aurora, CO, USA

Rebekah L. Gundry, PhD

University of Nebraska Medical Center, Omaha, NE, USA

Peipei Ping, PhD (Past Chair)

University of California, Los Angeles, CA, USA

Jennifer E. Van Eyk, PhD (Past Chair)

Cedars-Sinai Medical Center, Los Angeles, CA, USA

Executive Committee members:

Justyna Fert-Bober, PhD

Cedars-Sinai Medical Center, Los Angeles, CA, USA

Ying Ge, PhD

University of Wisconsin-Madison, USA

Anthony Gramolini, PhD

University of Toronto, Ontario, Canada

Jonathan Kirk, PhD

Loyola University Chicago, IL, USA

Edward Lau, PhD

University of Colorado, Aurora, CO, USA

Merry Lindsey, PhD

University of Nebraska Medical Center, Omaha, NE, USA

Manuel Mayr, MD, PhD

King's College London, London, UK

Mary Papadaki, PhD

Loyola University Chicago, IL, USA

Melanie White, PhD

University of Sydney, Sydney, Australia

Early Career Researchers:

Elizabeth Bayne, BA

University of Wisconsin-Madison, USA

Linda Berg Luecke, MS

University of Nebraska Medical Center, Omaha, NE, USA

Thomas Martin, BS

University of Colorado, Boulder, USA

Sabari Subramanian, PhD

University of Nebraska Medical Center, Omaha, NE, USA

Mission and Goals

Cardiovascular diseases are a leading cause of mortality and morbidity in the world. Despite ongoing efforts, current options for diagnosis and treatment are limited, and the underlying molecular mechanisms that lead to the manifestation of detrimental phenotypes in the heart remain largely elusive. The major goals of the HUPO Cardiovascular Initiative are to develop and apply cutting-edge proteomics and other omics technologies to map the dynamic cardiac and vascular proteomes, elucidate cardiovascular disease mechanisms, identify candidate therapeutic targets, and provide clinically useful diagnosis as well as risk prediction. 

Our Work

Emphasis is given to elucidating the complete cardiovascular proteome at single cell and proteoform resolution, and applying large-scale screening toward clinical diagnostics and prognosis of heart diseases. 


  • Cai W, Zhang J, de Lange WJ, Gregorich ZR, Karp H, Farrell ET, Mitchell SD, Tucholski T, Lin Z, Biermann M, McIlwain SJ, Ralphe JC, Kamp TJ, Ge Y. An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Res. 2019 Nov 8;125(11):936-953. doi: 10.1161/CIRCRESAHA.119.315305. Epub 2019 Oct 1. PMID: 31573406; PMCID: PMC6852699.

  • Herrington DM, Mao C, Parker SJ, Fu Z, Yu G, Chen L, Venkatraman V, Fu Y, Wang Y, Howard TD, Jun G, Zhao CF, Liu Y, Saylor G, Spivia WR, Athas GB, Troxclair D, Hixson JE, Vander Heide RS, Wang Y, Van Eyk JE. Proteomic Architecture of Human Coronary and Aortic Atherosclerosis. Circulation. 2018 Jun 19;137(25):2741-2756. doi: 10.1161/CIRCULATIONAHA.118.034365. PMID: 29915101; PMCID: PMC6011234.

  • Lau E, Cao Q, Lam MPY, Wang J, Ng DCM, Bleakley BJ, Lee JM, Liem DA, Wang D, Hermjakob H, Ping P. Integrated omics dissection of proteome dynamics during cardiac remodeling. Nat Commun. 2018 Jan 9;9(1):120. doi: 10.1038/s41467-017-02467-3. PMID: 29317621; PMCID: PMC5760723.

  • Lau E, Han Y, Williams DR, Thomas CT, Shrestha R, Wu JC, Lam MPY. Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome. Cell Rep. 2019 Dec 10;29(11):3751-3765.e5. doi: 10.1016/j.celrep.2019.11.026. PMID: 31825849; PMCID: PMC6961840.

  • Lee SH, Hadipour-Lakmehsari S, Murthy HR, Gibb N, Miyake T, Teng ACT, Cosme J, Yu JC, Moon M, Lim S, Wong V, Liu P, Billia F, Fernandez-Gonzalez R, Stagljar I, Sharma P, Kislinger T, Scott IC, Gramolini AO. REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. Nat Commun. 2020 Feb 19;11(1):965. doi: 10.1038/s41467-019-14143-9. PMID: 32075961; PMCID: PMC7031342.

  • Li DK, Smith LE, Rookyard AW, Lingam SJ, Koay YC, McEwen HP, Twigg SM, Don AS, O'Sullivan JF, Cordwell SJ, White MY. Multi-omics of a pre-clinical model of diabetic cardiomyopathy reveals increased fatty acid supply impacts mitochondrial metabolic selectivity. J Mol Cell Cardiol. 2022 Mar;164:92-109. doi: 10.1016/j.yjmcc.2021.11.009. Epub 2021 Nov 24. PMID: 34826416.

  • Martin TG, Myers VD, Dubey P, Dubey S, Perez E, Moravec CS, Willis MS, Feldman AM, Kirk JA. Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover. Nat Commun. 2021 May 19;12(1):2942. doi: 10.1038/s41467-021-23272-z. PMID: 34011988; PMCID: PMC8134551.

  • Papadaki M, Kampaengsri T, Barrick SK, Campbell SG, von Lewinski D, Rainer PP, Harris SP, Greenberg MJ, Kirk JA. Myofilament glycation in diabetes reduces contractility by inhibiting tropomyosin movement, is rescued by cMyBPC domains. J Mol Cell Cardiol. 2022 Jan;162:1-9. doi: 10.1016/j.yjmcc.2021.08.012. Epub 2021 Sep 3. PMID: 34487755; PMCID: PMC8766917.

  • Wojtkiewicz M, Berg Luecke L, Castro C, Burkovetskaya M, Mesidor R, Gundry RL, Bottom-up proteomic analysis of human adult cardiac tissue and isolated cardiomyocytes. J Mol Cell Cardiol. 2022 Jan;162:20-31. doi: 10.1016/j.yjmcc.2021.08.008. PMID: 34437879

Cardiovascular initiative membership:

Come join us! Let us know ( if you are interested in joining our Initiative! 

Announcements & upcoming events

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