Log in


Log in


Publications Publications

About The HPP


The Human Proteome Project (HPP) is an international project organized by the Human Proteome Organization (HUPO) that aims to revolutionize our understanding of the human proteome via a coordinated effort by many research laboratories around the world. It is designed to map the entire human proteome in a systematic effort using currently available and emerging techniques. Completion of this project will enhance understanding of human biology at the cellular level and lay a foundation for development of diagnostic, prognostic, therapeutic, and preventive medical applications.

Four Pillars

The four pillars of the HPP are Mass Spectrometry (MS), Antibodies (Abs), the Knowledgebase (KB), and Pathology (Path). These four pillars form the foundation upon which the chromosome-based HPP and the biology/disease HPP are conceived.

Chromosome-based Human Proteome Project (C-HPP)

The chromosome-based HPP aims to expand our understanding of the human proteome with a focus on expanding the understanding of each and every gene on each chromosome.

Biology/Disease Human Proteome Project (B/D-HPP)

The biology/disease-based HPP aims to expand our understanding of the human proteome with a focus on important biology research aspects and ongoing disease-focused research.

View the 2019 Annual Report of the HPP. 

The Grand Project - a function for every human protein

  • Build upon the large resources constructed through the significant efforts of the HPP
  • Understand the Proteome in the context of Networks of Networks
  • Partner with complementary consortia to expand the reach of the HPP and increase its relevance
  • Develop forward thinking strategies to provide functional information of each protein
  • Be a focal point for translational researchers for mechanisms, diagnostics, and therapeutics to improve human health

Download the white paper (Nov 12, 2021) by Rob Moritz

The Grand Project is:

  • Open to all interested groups or individuals
  • Agnostic to disease and biological context

The Grand Project will:

  • Utilize resources already familiar to the research group
  • Advance the knowledge of systems being worked on through the access to resources to perturb these systems

                                                 To participate to the HPP Grand Project please contact us

The Human Proteome Organization is a 501(c)(3) tax exempt non-profit organization registered in the state of New Mexico.  |  © 2001-2022 HUPO. All rights reserved. 

Powered by Wild Apricot Membership Software