About the HPP
The Human Proteome Project (HPP) is an international project organized by the Human Proteome Organization (HUPO) that aims to revolutionize our understanding of the human proteome via a coordinated effort by many research laboratories around the world. It is designed to map the entire human proteome in a systematic effort using currently available and emerging techniques. Completion of this project will enhance understanding of human biology at the cellular level and lay a foundation for development of diagnostic, prognostic, therapeutic, and preventive medical applications. Visit the HPP website for detailed information.
The three pillars of the HPP are Mass Spectrometry (MS), Affinity-Based Protein Capture (ABpC), and the Knowledgebase (KB). These three pillars form the foundation upon which the chromosome-based HPP and the biology/disease HPP are conceived.
Chromosome-based Human Proteome Project (C-HPP)
The chromosome-based HPP aims to expand our understanding of the human proteome with a focus on expanding the understanding of each and every gene on each chromosome. Additional information is available at the C-HPP portal.
Biology/Disease Human Proteome Project (B/D-HPP)
The biology/disease-based HPP aims to expand our understanding of the human proteome with a focus on important biology research aspects and ongoing disease-focused research.
Many of the B/D groups were independent HUPO initiatives prior to the development of the HPP structure and some are newly formed. There are three groups that continue to function as independent HUPO initiatives as well as under the B/D branch of the HPP.
Biology and Disease-Driven Groups of the HPP (B/D – HPP)
- Antibodies (also functions as an independent HUPO initiative)
- Diabetes (HDPP)
- Epigenetic Chromatin
- Extreme Conditions
- Food and Nutrition
- Glycoproteomics (also functions as an independent HUPO initiative)
- Human Immuno-Peptidome Project (HIPP)
- iMOP (also functions as an independent HUPO initiative)
- Kidney Urine
- Protein Misfolding and Aggregation
- Stems Cells
- Skeletal Muscle Proteome