Despite the extensive focus on various physiological and pathological proteomes it has been almost exclusively carried out in adults. There has been a clear lack of paediatric specific proteomic studies. This limitation has the greatest impact on disease prevention as it relies on early detection and children are the perfect candidates. For example, detection of biomarkers of adult diseases in early childhood can contribute to disease prevention and ultimately result in a significant reduction in burden of disease and disease related costs on individuals and health care systems. Furthermore, paediatric patient-based biomarker studies are significantly simplified as children tend to suffer from only one condition at a time, in contrast to adult patient population where other confounding co-morbidities have to be often considered. The Pediatric Proteome Initiative, begun in 2014 as an international effort, to solve major issues in Paediatric Medicine.
Current lines of work:
- To characterize the normal paediatric proteome from birth until adulthood.
- Coordinate longitudinal disease studies by creating a worldwide paediatric biorepository network and inventory
- To standardize the protocols for paediatric specific proteomic studies (including sample collection, storage, standards, etc.).
- To provide a platform to disseminate information and resources to address the special requirements for clinical and translational proteomics studies focused on paediatric patients.
- To establish a framework that facilitates training, communication/collaboration between individuals that have access to the latest proteomic techniques with the clinicians that have access to specific paediatric populations that need to be investigated.
- To enhance capabilities for translational research by providing a common forum and a strong network for collaboration between clinicians and scientists.
- To facilitate studies in the setting of major and unique diseases affecting the pediatric population (i.e. Infectious Diseases, Birth Defects, Genetic Defects, Autism Spectrum Disorders, Diabetes, Obesity).
- To utilize the knowledge of the paediatric proteome for the prevention of adult diseases (i.e. CVD, Diabetes, Obesity).
Everett A, Ignjatovic V.
Paediatrics and proteomics: back to the beginning. Proteomics Clin Appl. 2014
Vera Ignjatovic, Co-Chair
Hanno Steen, Co-Chair
Allen Everett, Co-Chair