Human Proteome Project (HPP)
Mission Statement of HPP
The mission of the Human Proteome Project (HPP): “The Human Proteome Project, by characterizing all 21 000 genes of the known genome, will generate the map of the protein based molecular architecture of the human body and become a resource to help elucidate biological and molecular function and advance diagnosis and treatment of diseases ”
HPP as seen around the World
Click here to link to a page dedicated to how the HPP is seen around the world...News from the HPP Working Group
- Report from the Kick Off Meeting January 2010
- Report from the Second Meeting May 10 2010
- Report for Sydney HPP Meetings September 19 and 23, 2010
- Report for Busan HPP Meetings March 30, 2011 and download slides
Two sessions featuring the Human Proteome Project (HPP) took place as part of the HUPO 9th Annual World Congress in Sydney, in September 2010.
The first was an open session of the HPP Working Group, held on Sunday, September 19th, which addressed major issues stemming from a draft document that had been circulating among interested parties over the previous two weeks. Part of the session was also devoted to preparing the official HPP launch session planned for Thursday, September 23rd.
This second session consisted of a presentation (view here) followed by a general discussion. That discussion resulted in a general agreement (by show of hands) from the audience that HPP should be launched with the understanding that its first priority should be to define long term (10 years) deliverables and detailed short term (5 years) deliverables and milestones.
The HPP consortium will coordinate initiatives structured by chromosome built for gathering knowledge on proteins. A general document presenting the goals, objectives and action plan for HPP should be made publicly available and published in proteomics journals very soon.
A workshop took place in Busan (Korea) on March 30, 2011 for the creation of the HPP consortium. A short summary of the discussion is provided, followed by the recommendations and decisions forwarded to the HUPO Executive committee that validated these decisions on April 5, 2011.
Key Documents Related to Activities
The human proteome project: Current state and future direction - coming soon
The call of the human proteome - Nature Methods 7, 661-661 (September 2010) doi:10.1038/nmeth0910-661 Editorial
Mass spectrometry in high-throughput proteomics: ready for the big time Tommy Nilsson, Matthias Mann, Ruedi Aebersold, John R Yates, Amos Bairoch, John J M Bergeron Nature Methods 7, 681-685 (September 2010) doi:10.1038/nmeth0910-681 Commentary
Rabilloud, T., Hochstrasser, D. and Simpson, R. J. (2010), Is a gene-centric human proteome project the best way for proteomics to serve biology?. PROTEOMICS, 10: 3067–3072. doi: 10.1002/pmic.201000220 .
HUPO Views (Feb 2010): "A Gene Centric Human Proteome Project" Mol Cell Proteomics 9 (2): 427.
Building the 'practical' human proteome project - the next big thing in basic and clinical proteomics. Curr Opin Mol Ther. 2009 Dec;11(6):600-2.
Proteomonitor - Human Proteome Project Revisited at HUPO; Methodology, Funding, Data Management Still Open Questions - Sept 28, 2009
- Human Proteome Project White Paper The "white paper" on the Human Proteome Project was written in August 2008. It was inspired by intense discussions during the 4th international Barbados Proteomics Conference that took place in January 2008. This paper was one of the major sources of inspiration of the HUPO Views article (MCP, Feb 2010).
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JPR - HUPO’s Human Proteome Project: the next big thing? – May 6, 2008
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Nature - Biologists initiate plan to map human proteome –Nature Vol 452 24 April 2008
- HUPO Test Sample Related Papers:
(May 17, 2009) Press Release: HUPO has now published (Nature Methods) the results of a three-year quality control study. <read the press release>
Nature Methods - A HUPO test sample study reveals common problems in mass spectrometry–based proteomics Nature Methods 6, 423 - 430 (2009)
Nature Methods - a stress test for mass spectrometry–based proteomics - nature methods | VOL.6 NO.6 | JUNE 2009
Nature Methods - Comparative analysis to guide quality improvements in proteomics - nature methods | VOL.6 NO.10 | OCTOBER 2009
HPP Events
Upcoming Events
Already took place
- Busan, South Korea - March 30 2011
- HUPO 9th Annual World Congress, Sydney 2010 www.hupo2010.com
- HPP Canadian National Proteomics Network's (CNPN) brain storming session, Montreal - January 17, 2010
- CNPN /canadian Funding Agencies meeting, Montreal - January 18, 2010
- HPP Working Group Kickoff Meeting, Seattle - January 25, 2010 - View Report
- European Scientific Foundation (ESF) HPP scoping meeting - February 26, 2010
- HPP Working Group second meeting, Montreal - May 10, 2010 - View Report
- Canadian HPP workshop, Montréal, May 11, 2010
