Human Brain Proteome Project
Overview of Project
The HUPO Brain Proteome Project is an open, international scientific initiative that welcomes additional groups and laboratories. Our focus is on human neurodegenerative diseases and their corresponding mouse models - specifically, Alzheimer`s Disease (AD including Down-Syndrome), Parkinson`s Disease (PD) and Aging.
The goals of this project are as follows:
- Define and decipher normal brain proteome including polymorphisms, modifications, histological localization as well as identification of brain derived proteins in bodily fluids.
- Correlate the expression pattern of brain proteins and mRNA.
- Identify, validate, and functionally characterize disease-related proteins involved in neurodegenerative diseases and aging by differential protein expression profiling and by techniques and methods available within the participating groups in order to get biomarkers for diagnostic and therapeutic targets.
- Elucidate other neurodegenerative diseases via the additional of additional research laboratories.
- Develop education and training programs in order to inform the public and propagate standardized proteomic techniques and methods.
- Establish, a neuroproteomic data base accessible to all participating laboratories and the scientific community.
Collaborations with other Initiatives
Strong collaborative relationships are in place with:
- HUPO Proteomic Standards Initiative (PSI) - for bioinformatics and standardization efforts
- HUPO Liver Proteome Project - via governmental Chinese-German Cooperation
- HUPO Plasma Proteome Project
Key Documents Related to Activities
- Agenda for the December 15-16, 2005 meeting
- BPP workshop, February 15-16 2006
- Conway Campus Map
- ProteinScape Training Course, Dortmund, Germany November 29, 2005
- Editorial article on June 2005 HBPP meeting
- BPP and NGFN are planning a Dementia Workshop in December 2005
For a more detailed list please go to:
